True nanoflow LCMS system equipped with Deans’ switching system (left) and modified ESI interface (below). The column is butt-connected to the emitter in a 360um ID sleeve (detail). Post column dead volume less than 5 nL
Hearth of Nanoseparations' switching system. The trap column is mounted between 2 u-T's, creating the lowest pre-column dead volume.

Nanoseparations' Column Switching System.

Nanoseparations has developed an effective column switching technology based on remote directing of the HPLC solvent stream simply by switching a 6-port valve. Advantages include: